Стереотактическая радиохирургия для трехгеминской нейронгии в качестве вторичной до множественного склероза: систематический обзор и мета-анализ.
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Hajikarimloo Bardia, Tos Salem M, Mohammadzadeh Ibrahim, Aarabi Aryan, Moslehi Sara, Jabbaripour Sama, Sadraei Samin, Hasanzade Arman, Najari Dorsa, Ebrahimi Azin, Habibi Mohammad Amin
Аннотация
Оригинал публикации
Stereotactic radiosurgery for trigeminal neuralgia secondary to Multiple Sclerosis: A systematic review and Meta-Analysis.
BACKGROUND: The management of trigeminal neuralgia secondary to multiple sclerosis (MS-TN) remains clinically challenging due to its refractory course and aggressive symptom pattern. Among available interventions, stereotactic radiosurgery (SRS) has emerged as a minimally invasive and effective option. This systematic review and meta-analysis aims to assess the efficacy and safety of SRS in patients with MS-related trigeminal neuralgia.
METHODS: A comprehensive literature search was conducted on March 26, 2025, to identify studies that reported pain-related outcomes and adverse radiation effects (AREs) in patients with MS-TN treated with SRS.
RESULTS: A total of 23 studies comprising 837 patients with MS-TN were analyzed. The mean follow-up period across studies ranged from 6.1 to 88.3 months. Pooled results demonstrated an initial pain-free rate of 32 % (95 % CI: 13-55 %) and an initial adequate pain-relief rate of 74 % (95 % CI: 50-92 %). At the final follow-up, the pain-free rate was 17 % (95 % CI: 5-32 %), while adequate pain relief was maintained in 65 % (95 % CI: 50-78 %) of patients. The pooled incidence of AREs following SRS was 9 % (95 % CI: 2-18 %).
CONCLUSIONS: SRS shows promising pain outcomes and a low rate of AREs in patients with MS-TN. Nonetheless, larger comparative investigations are required to evaluate different SRS approaches and to determine how MS subtypes may influence treatment response.