The Journal of dermatological treatment · 2009
Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Driessen Rieke J B, Boezeman Jan B, Van De Kerkhof Peter C M, De Jong Elke M G J
Аннотация
BACKGROUND: The associations between psoriasis and cardiovascular risk factors are reported to be stronger as psoriasis severity increases. This makes studying cardiovascular risk factors in high-need psoriasis patients, eligible for biological therapy, interesting.
OBJECTIVE: To survey the prevalence of cardiovascular risk factors in high-need psoriasis patients and to compare these data to patients with other dermatological diseases. Furthermore, the implications of these findings for treatment with biologics were outlined.
METHODS: The prevalence of cardiovascular risk factors was investigated in a high-need psoriatic patient cohort and compared to patients with other skin diseases who filled out a questionnaire about the presence of cardiovascular risk factors.
RESULTS: A significantly higher prevalence of obesity, smoking, and hypertension was found for the high-need psoriatic patients' cohort compared with non-psoriatic controls. Striking differences were found with respect to body mass index and obesity, as 35.5% of all high-need psoriatic patients were obese.
CONCLUSIONS: High-need psoriatic patients show a high prevalence of cardiovascular risk factors, and may consequently be predisposed to cardiovascular diseases. As this is relevant for therapy management in daily clinical practice, especially biologics, cardiovascular risk should be evaluated for each high-need psoriasis patient before and during systemic treatment.
OBJECTIVE: To survey the prevalence of cardiovascular risk factors in high-need psoriasis patients and to compare these data to patients with other dermatological diseases. Furthermore, the implications of these findings for treatment with biologics were outlined.
METHODS: The prevalence of cardiovascular risk factors was investigated in a high-need psoriatic patient cohort and compared to patients with other skin diseases who filled out a questionnaire about the presence of cardiovascular risk factors.
RESULTS: A significantly higher prevalence of obesity, smoking, and hypertension was found for the high-need psoriatic patients' cohort compared with non-psoriatic controls. Striking differences were found with respect to body mass index and obesity, as 35.5% of all high-need psoriatic patients were obese.
CONCLUSIONS: High-need psoriatic patients show a high prevalence of cardiovascular risk factors, and may consequently be predisposed to cardiovascular diseases. As this is relevant for therapy management in daily clinical practice, especially biologics, cardiovascular risk should be evaluated for each high-need psoriasis patient before and during systemic treatment.
Предметные рубрики MeSH
AdultAge DistributionAlcoholismCardiovascular DiseasesCase-Control StudiesCombined Modality TherapyComorbidityFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisObesityProbabilityPrognosisPsoriasisReference ValuesRisk FactorsSeverity of Illness IndexSex DistributionSmokingSurvival Rate