Cell · 2018
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kim Hyeonwoo, Wrann Christiane D, Jedrychowski Mark, Vidoni Sara, Kitase Yukiko, Nagano Kenichi, Zhou Chenhe, Chou Joshua, Parkman Virginia-Jeni A, Novick Scott J, Strutzenberg Timothy S, Pascal Bruce D, Le Phuong T, Brooks Daniel J, Roche Alexander M, Gerber Kaitlyn K, Mattheis Laura, Chen Wenjing, Tu Hua, Bouxsein Mary L, Griffin Patrick R, Baron Roland, Rosen Clifford J, Bonewald Lynda F, Spiegelman Bruce M
Аннотация
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Here we show that irisin binds to proteins of the αV class of integrins, and biophysical studies identify interacting surfaces between irisin and αV/β5 integrin. Chemical inhibition of the αV integrins blocks signaling and function by irisin in osteocytes and fat cells. Irisin increases both osteocytic survival and production of sclerostin, a local modulator of bone remodeling. Genetic ablation of FNDC5 (or irisin) completely blocks osteocytic osteolysis induced by ovariectomy, preventing bone loss and supporting an important role of irisin in skeletal remodeling. Identification of the irisin receptor should greatly facilitate our understanding of irisin's function in exercise and human health.