Archives of dermatology · 1997
Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders.
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Iwatsuki K, Ohtsuka M, Harada H, Han G, Kaneko F
Аннотация
OBJECTIVE: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection.
DESIGN: Retrospective survey of case series.
SETTING: University hospital medical center.
PATIENTS: Sixty-five patients with cutaneous lymphomas and related disorders.
MAIN OUTCOME MEASURES: Detection of EBV genes and EBV-encoded small nuclear RNAs.
RESULTS: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sézary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis.
CONCLUSION: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sézary syndrome.
DESIGN: Retrospective survey of case series.
SETTING: University hospital medical center.
PATIENTS: Sixty-five patients with cutaneous lymphomas and related disorders.
MAIN OUTCOME MEASURES: Detection of EBV genes and EBV-encoded small nuclear RNAs.
RESULTS: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sézary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis.
CONCLUSION: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sézary syndrome.
Предметные рубрики MeSH
AdolescentAdultAgedAntisense Elements (Genetics)Base SequenceBiopsyChildDNA PrimersDNA, ViralFemaleHerpesviridae InfectionsHerpesvirus 4, HumanHumansIn Situ HybridizationLymphoproliferative DisordersMaleMiddle AgedMolecular Sequence DataPolymerase Chain ReactionRetrospective StudiesTumor Virus Infections