European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
Muscle-specific strength is an alternative to muscle mass and grip strength for predicting outcomes in patients with gastric cancer.
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Wang Su-Lin, Chen Chen-Bin, Huang Yun-Shi, Ruan Xiao-Jiao, Cheng Jun, Shen Xian, Dong Qian-Tong
Аннотация
BACKGROUND: Muscle-specific strength is a newly proposed indicator for assessing muscle quality. Its prognostic value in patients undergoing cancer surgery remains unclear. This study aims to evaluate the impact of low muscle-specific strength on short- and long-term outcomes in patients with resectable gastric cancer.
METHODS: Patient data were prospectively collected from 2013 to 2019 for individuals diagnosed with gastric cancer. Muscle-specific strength was determined by calculating the ratio of grip strength to skeletal muscle area. Reference values for low muscle-specific strength were calculated using optimal stratification with X-tile software. Survival outcomes were analyzed using Kaplan-Meier survival curves and multivariate Cox proportional hazards models.
RESULTS: A total of 1404 patients were included, comprising 1030 males (73.4 %) and 374 females (26.6 %) with a median age of 66 years. Low muscle-specific strength was identified as an independent risk factor for severe postoperative complications (OR = 2.026, 95 % CI = 1.115-3.684, P = 0.021) and overall survival (HR = 1.385, 95 % CI = 1.072-1.789, P = 0.013). In the subgroup analysis, low muscle-specific strength emerged as an independent risk factor for both postoperative severe complications (HR = 1.938, 95 % CI = 1.024-3.668, P = 0.042) and overall survival (HR = 1.359, 95 % CI = 1.017-1.816, P = 0.038) in males, but not in females. A combination of low muscle strength, low muscle-specific strength, and low muscle mass exhibited a better prognostic value for mortality risk than any two-factor combination or individual indicator.
CONCLUSIONS: Muscle-specific strength may serve as a reliable alternative to traditional sarcopenia criteria in predicting the prognosis of surgical oncology patients. The integration of multiple muscle-related indicators can further enhance risk stratification for adverse outcomes.
METHODS: Patient data were prospectively collected from 2013 to 2019 for individuals diagnosed with gastric cancer. Muscle-specific strength was determined by calculating the ratio of grip strength to skeletal muscle area. Reference values for low muscle-specific strength were calculated using optimal stratification with X-tile software. Survival outcomes were analyzed using Kaplan-Meier survival curves and multivariate Cox proportional hazards models.
RESULTS: A total of 1404 patients were included, comprising 1030 males (73.4 %) and 374 females (26.6 %) with a median age of 66 years. Low muscle-specific strength was identified as an independent risk factor for severe postoperative complications (OR = 2.026, 95 % CI = 1.115-3.684, P = 0.021) and overall survival (HR = 1.385, 95 % CI = 1.072-1.789, P = 0.013). In the subgroup analysis, low muscle-specific strength emerged as an independent risk factor for both postoperative severe complications (HR = 1.938, 95 % CI = 1.024-3.668, P = 0.042) and overall survival (HR = 1.359, 95 % CI = 1.017-1.816, P = 0.038) in males, but not in females. A combination of low muscle strength, low muscle-specific strength, and low muscle mass exhibited a better prognostic value for mortality risk than any two-factor combination or individual indicator.
CONCLUSIONS: Muscle-specific strength may serve as a reliable alternative to traditional sarcopenia criteria in predicting the prognosis of surgical oncology patients. The integration of multiple muscle-related indicators can further enhance risk stratification for adverse outcomes.