Сверхвековое воспоминание ассоциируется с дисрегулированными микроглиальными переходами.
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Zia Sameera, Traetta Marianela E, Baaklini Charbel S, Hammond Brady P, John Rebecca K, Souter Katherine M, Meijns Niels, Afun Larry K A, Panda Sharmistha, González Ibáñez Fernando, Burr Mena K, Dhupia Eva, Rathod Abhisha M, Faria Andre O, Zaveri Dhruvish, Challa Sowmya, Hahn Eugene, Manesh Sohrab B, Lee Kelly V, Ho Madelene F S, Friedman Timothy N, Maguire Aislinn D, Pang Arina, Farkas Olivia, Szulc Bożena, Tenorio Luiz, Vyas Diya, La Caprara Olivia R, Tetzlaff Wolfram, Sinha Sarthak, Duncan Gregory J, Voronova Anastassia, Kerr Bradley J, Tremblay Marie-Eve, Biernaskie Jeff, Schenk Geert, Plemel Jason R
Аннотация
Оригинал публикации
Age-impaired remyelination is associated with dysregulated microglial transitions.
Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and is impaired with age. Remyelination is facilitated by microglia but our understanding of the microglial response during remyelination is incomplete. Here, we profile the microglial response during remyelination in the lysolecithin mouse model using single-cell RNA sequencing and find several distinct microglial states during the early stages of remyelination that coalesce into a resolved state defined by the presence of myelin transcripts, a state also present in MS brains. We also observe a delay in the appearance of several microglial states with age, in concordance with delayed remyelination. This multi-faceted microglial response during efficient remyelination provides the basis of multi-faceted microglia-specific targets for future MS therapies.