Усталость, депрессия и связанное со здоровьем качество жизни в педиатрическом многоразовом склерозе: сравнительное исследование из центра третичной медицинской помощи.
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Karaca Nazlı Balcan, Akbaş Salih, Kuzu Kumcu Müge, Demir Ercan, Gücüyener Kıvılcım
Аннотация
Оригинал публикации
Fatigue, depression, and health-related quality of life in pediatric-onset multiple sclerosis: A comparative study from a tertiary care center.
BACKGROUND: Fatigue, depression, and decreased health-related quality of life (HRQoL) are commonly reported among patients with pediatric-onset multiple sclerosis (POMS). However, their interplay and distinct manifestations remain insufficiently understood.
OBJECTIVE: This study aimed to assess fatigue, depressive symptoms, and HRQoL in a well-characterized cohort of POMS patients in comparison to age- and sex-matched healthy controls (HCs).
METHODS: Participants completed the Fatigue Severity Scale (FSS), the 36-Item Short Form Survey (SF-36), and the Revised Children's Anxiety and Depression Scale (RCADS). Comparative analyses between groups were conducted using standard parametric and non-parametric statistical tests.
RESULTS: A total of 41 patients with POMS (mean age: 17.98 ± 1.94 years; 75.6 % female) and 35 healthy controls (mean age: 17.43 ± 1.17 years; 60 % female) were enrolled. Fatigue was significantly more prevalent and severe in the POMS group, as evidenced by higher FSS scores (p = 0.006) and increased fatigue rates (22 % vs. 2.8 %, p = 0.026). No significant between-group differences were found in depression or anxiety scores (p > 0.05). In the SF-36, POMS patients exhibited significantly lower vitality (p = 0.009) and general health scores (p = 0.001), whereas other domains remained comparable.
CONCLUSION: Fatigue and reduced perceptions of vitality and general health are prominent concerns in POMS, even in the absence of overt depressive or anxiety symptoms. These findings underscore the need for early integration of psychological assessments and fatigue-specific interventions within multidisciplinary care to enhance long-term quality of life.