The Journal of rheumatology · 2019
Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sewerin Philipp, Schleich Christoph, Brinks Ralph, Müller-Lutz Anja, Fichter Florian, Eichner Markus, Schneider Matthias, Ostendorf Benedikt, Vordenbäumen Stefan
Аннотация
OBJECTIVE: To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).
METHODS: Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.
RESULTS: Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).
CONCLUSION: Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.
METHODS: Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.
RESULTS: Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).
CONCLUSION: Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.