Indian pediatrics · 2014
Plasma exchanges and immunosuppression for anti-complement factor H associated hemolytic uremic syndrome.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Khandelwal Priyanka, Sinha Aditi, Hari Pankaj, Bagga Arvind
Аннотация
BACKGROUND: Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure.
CASE CHARACTERISTICS: 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies.
INTERVENTION: Prompt initiation of plasma exchanges and immunosuppression.
OUTCOME: Remission of hematological and kidney functions.
MESSAGE: Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.
CASE CHARACTERISTICS: 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies.
INTERVENTION: Prompt initiation of plasma exchanges and immunosuppression.
OUTCOME: Remission of hematological and kidney functions.
MESSAGE: Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.