The Journal of hand surgery · 2010
Complications of radiation therapy to the hand after soft tissue sarcoma surgery.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Rohde Rachel S, Puhaindran Mark E, Morris Carol D, Alektiar Kaled M, Schupak Karen D, Healey John H, Athanasian Edward A
Аннотация
PURPOSE: Radiation has been shown to improve local control after resection of soft tissue sarcomas. However, it may also result in major complications in the hand, given the compact nature of functional tissues and limited tissue volumes in the hand. The purpose of this investigation was to describe the hand-specific complications of radiation therapy for patients with soft tissue sarcoma of the hand (STSH).
METHODS: We performed a retrospective chart review of 55 consecutive patients with STSH treated by a single surgeon between 1993 and 2006. We identified 26 patients who were treated with external beam radiation, brachytherapy, or both, either preoperatively or postoperatively, and reviewed their clinical course.
RESULTS: After a median follow-up of 7 years, 29 treatment-related complications occurred in 19 patients who had received radiation, whereas 3 of the 29 patients treated with surgery alone developed complications. All patients who received brachytherapy and 14 of the 21 treated with external beam radiation alone developed complications. There were 5 early minor, 2 early major, 3 late minor, and 19 late major complications.
CONCLUSIONS: Patients with STSH who underwent radiation therapy had a high rate of complications. The complication rate in our series was higher in patients who had brachytherapy catheters placed adjacent to finger joints. A better understanding of predictors of complications will help to determine the optimal timing and type of radiation therapy to treat patients with STSH.
TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
METHODS: We performed a retrospective chart review of 55 consecutive patients with STSH treated by a single surgeon between 1993 and 2006. We identified 26 patients who were treated with external beam radiation, brachytherapy, or both, either preoperatively or postoperatively, and reviewed their clinical course.
RESULTS: After a median follow-up of 7 years, 29 treatment-related complications occurred in 19 patients who had received radiation, whereas 3 of the 29 patients treated with surgery alone developed complications. All patients who received brachytherapy and 14 of the 21 treated with external beam radiation alone developed complications. There were 5 early minor, 2 early major, 3 late minor, and 19 late major complications.
CONCLUSIONS: Patients with STSH who underwent radiation therapy had a high rate of complications. The complication rate in our series was higher in patients who had brachytherapy catheters placed adjacent to finger joints. A better understanding of predictors of complications will help to determine the optimal timing and type of radiation therapy to treat patients with STSH.
TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overBrachytherapyChildCohort StudiesDose-Response Relationship, RadiationFemaleFollow-Up StudiesFractures, SpontaneousHandHumansIncidenceMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingOrthopedic ProceduresOsteoradionecrosisPostoperative CarePreoperative CareRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSarcomaTime FactorsTomography, X-Ray ComputedTreatment OutcomeYoung Adult