Archives of dermatology · 1975
Azaribine therapy for psoriasis. Evaluation of potential effects on the liver and other organ systems.
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Keefer R A, Roenigk H H, Hawk W A
Аннотация
An open study of azaribine was carried out on 38 psoriatic patients for two years. Thirty-five patients had previously taken methotrexate. Thirty-four patients had liver biopsies performed before azaribine therapy and 14 had liver biopsies performed after azaribine therapy. Of these 14, five had grade 1 liver biopsies before and after therapy; one had grade III before and after therapy; and three had grade IV before and after therapy. Liver biopsy findings were slightly worse in two patients, and three patients showed improvement in liver biopsy findings.