Multiple sclerosis and related disorders · 2025
Machine learning using clinical variables to screen for depression and anxiety in people with early multiple sclerosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Phillips Braxton, Morrow Sarah A, Singh Harasees, Oh Jiwon, Kolind Shannon, Lynd Larry D, Prat Alexandre, Tam Roger, Traboulsee Anthony, Patten Scott B, CanProCo Study Group
Аннотация
BACKGROUND: Depression and anxiety are more prevalent in people with multiple sclerosis (pwMS) than in the general population and are thus common psychiatric comorbidities in MS. As such, screening for psychiatric comorbidities in pwMS is an important component of MS care. However, large-scale screening efforts using scales that measure depressive symptoms with the goal of identifying a subgroup of pwMS with a high probability of depression, and thus in need of further assessment, have not been successful. Machine learning algorithms using routinely collected clinical information may be able to serve the same purpose without the encumbrance of scale administration and scoring.
METHODS: We used baseline clinical and demographic data collected in the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo). The Patient Health Questionnaire-9 (PHQ-9) was used to screen for symptoms of depression and the Generalized Anxiety Disorder-7 (GAD-7) for symptoms of anxiety. Machine learning with elastic net was used to develop logistic regression models to predict participant scores above traditional cut-off scores ≥10 that are indicative of clinically significant depression and anxiety.
RESULTS: Machine learning with elastic net produced a model that was able to predict scores ≥10 on the PHQ-9 in participants in the testing dataset with a high area under the curve (AUC = 0.927). Prediction of scores ≥10 on the GAD-7 in participants in the testing dataset was modest (AUC = 0.813). Final multivariable logistic regression models found that increased self-reported psychosocial fatigue (OR: 1.55, p < 0.001 and OR: 1.27, p = 0.0026), increased self-reported cognitive fatigue (OR: 1.08, p < 0.001 and OR: 1.08, p < 0.001), and number of comorbidities (OR: 1.26, p = 0.0015 and OR: 1.15, p = 0.041) were predictive of scoring above the cut-off on PHQ-9 and GAD-7, respectively.
CONCLUSION: The identification of psychiatric comorbidities such as depression in pwMS could be facilitated by making use of clinical variables with similar success to direct administration of rating scales.
METHODS: We used baseline clinical and demographic data collected in the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo). The Patient Health Questionnaire-9 (PHQ-9) was used to screen for symptoms of depression and the Generalized Anxiety Disorder-7 (GAD-7) for symptoms of anxiety. Machine learning with elastic net was used to develop logistic regression models to predict participant scores above traditional cut-off scores ≥10 that are indicative of clinically significant depression and anxiety.
RESULTS: Machine learning with elastic net produced a model that was able to predict scores ≥10 on the PHQ-9 in participants in the testing dataset with a high area under the curve (AUC = 0.927). Prediction of scores ≥10 on the GAD-7 in participants in the testing dataset was modest (AUC = 0.813). Final multivariable logistic regression models found that increased self-reported psychosocial fatigue (OR: 1.55, p < 0.001 and OR: 1.27, p = 0.0026), increased self-reported cognitive fatigue (OR: 1.08, p < 0.001 and OR: 1.08, p < 0.001), and number of comorbidities (OR: 1.26, p = 0.0015 and OR: 1.15, p = 0.041) were predictive of scoring above the cut-off on PHQ-9 and GAD-7, respectively.
CONCLUSION: The identification of psychiatric comorbidities such as depression in pwMS could be facilitated by making use of clinical variables with similar success to direct administration of rating scales.