Respiratory medicine · 2025
Ethnic variation in South East Asian patients with severe asthma: A first look at the Singapore Severe Asthma Registry (SSAR) and implications on clinical practice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Tay Tunn Ren, Pang Pee Hwee, Liew Mei Fong, Tiew Pei Yee, Tun Mon Hnin, Jaggi Tavleen Kaur, Lau Anna, Lim Hui Fang, Tan Genevieve, Yu-Fang Sieow Nicole, Chotirmall Sanjay H, Koh Mariko Siyue
Аннотация
BACKGROUND: Real world severe asthma registries in Asia are limited but important for understanding severe asthma in Asian populations.
OBJECTIVE: To describe the characteristics of a multi-ethnic cohort in the Singapore Severe Asthma Registry (SSAR), and examine differences between the 3 major ethnic groups (Chinese, Malay and Indian).
METHODS: Adult patients with severe asthma from 4 public hospitals in Singapore were enrolled into SSAR. The registry collected anonymized data including demographics, asthma control, comorbidities, investigations, and medication use.
RESULTS: 254 patients were recruited between 2022 and 2024. Patients were predominantly female (55.9 %) and Chinese (57.5 %). Median number of exacerbations in the past year was 2 (0-3); 61 patients (24 %) had ≥1 emergency department visit and 94 (37 %) had ≥1 hospital admission. 97.5 % of patients had a type 2 high inflammatory profile. 21.7 % and 17.7 % of patients were on biologics and maintenance oral corticosteroids, respectively. Ethnic differences were observed: Non-Chinese patients had the lowest Asthma Control Test scores (Chinese 18 ± 5, Malay 16 ± 5, Indian 16 ± 5, p = 0.011); Non-Chinese patients were more likely to have obesity (Chinese 17.7 %, Malay 50.9 %, Indian 40.9 % p < 0.001); Indian patients were most likely to have diabetes mellitus (Chinese 16.6 %, Malay 18.2 %, Indian 38.6 %, p = 0.006)) while Chinese patients were most likely to have osteoporosis (Chinese 14.5 %, Malay 0 %, Indian 2.3 %, p = 0.001). Cluster analysis identified 4 distinct clusters with different comorbidity profiles and exacerbation outcomes.
CONCLUSION: This study provided the first look into data from the Singapore Severe Asthma Registry; ethnic differences were observed, especially in comorbidity risks.
OBJECTIVE: To describe the characteristics of a multi-ethnic cohort in the Singapore Severe Asthma Registry (SSAR), and examine differences between the 3 major ethnic groups (Chinese, Malay and Indian).
METHODS: Adult patients with severe asthma from 4 public hospitals in Singapore were enrolled into SSAR. The registry collected anonymized data including demographics, asthma control, comorbidities, investigations, and medication use.
RESULTS: 254 patients were recruited between 2022 and 2024. Patients were predominantly female (55.9 %) and Chinese (57.5 %). Median number of exacerbations in the past year was 2 (0-3); 61 patients (24 %) had ≥1 emergency department visit and 94 (37 %) had ≥1 hospital admission. 97.5 % of patients had a type 2 high inflammatory profile. 21.7 % and 17.7 % of patients were on biologics and maintenance oral corticosteroids, respectively. Ethnic differences were observed: Non-Chinese patients had the lowest Asthma Control Test scores (Chinese 18 ± 5, Malay 16 ± 5, Indian 16 ± 5, p = 0.011); Non-Chinese patients were more likely to have obesity (Chinese 17.7 %, Malay 50.9 %, Indian 40.9 % p < 0.001); Indian patients were most likely to have diabetes mellitus (Chinese 16.6 %, Malay 18.2 %, Indian 38.6 %, p = 0.006)) while Chinese patients were most likely to have osteoporosis (Chinese 14.5 %, Malay 0 %, Indian 2.3 %, p = 0.001). Cluster analysis identified 4 distinct clusters with different comorbidity profiles and exacerbation outcomes.
CONCLUSION: This study provided the first look into data from the Singapore Severe Asthma Registry; ethnic differences were observed, especially in comorbidity risks.