Emerging infectious diseases · 2025
Corynebacterium diphtheriae Infections, South Africa, 2015-2023.
Историческая статьяСтатьяНазвание и аннотация: Перевод в очереди
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du Plessis Mignon, Mikhari Rito, de Gouveia Linda, Duma Noluthando, Lovelock Tamsin, Lawrence Charlene, Mahabeer Prasha, Mahabeer Yesholata, Govender Nevashan, Nzenze Susan, Featherston Jonathan, Moodley Mishalan, Moyes Jocelyn, Walaza Sibongile, Cohen Cheryl, von Gottberg Anne
Аннотация
We reviewed Corynebacterium spp. infection cases reported in South Africa during 2015-2023. We analyzed 84 isolates from 83 patients with C. diphtheriae, as well as 1 C. belfantii and 3 C. ulcerans isolates. Among C. diphtheriae cases, we observed respiratory diphtheria (26/83 patients [31%]), endocarditis (14/83 [17%]), cutaneous diphtheria (22/83 [27%]), nonspecific respiratory illnesses (5/83 [6%]), and asymptomatic carriage (16/83 [19%]). The median patient age was 19 (range 0-88) years. Diphtheria-tetanus-pertussis vaccination was incomplete for 26% (5/19) or unknown for 68% (13/19) of children 0-9 years of age. C. diphtheriae was intermediately resistant to penicillin (82/84 [98%] isolates; MIC90 0.5 μg/mL) but susceptible to erythromycin (83/84 [99%] isolates; MIC90 0.25 μg/mL). Eighteen unique sequence types were identified, corroborating C. diphtheriae heterogeneity. Toxin-producing strains were detected among cutaneous and respiratory diphtheria cases, indicating all forms of disease require monitoring and prompt public health action to curb transmission.