Emerging infectious diseases · 2024
Retrospective Study of Infections with Corynebacterium diphtheriae Species Complex, French Guiana, 2016-2021.
СтатьяМногоцентровое исследованиеИсторическая статьяНазвание и аннотация: Перевод в очереди
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Gaillet Mélanie, Hennart Mélanie, Rose Vincent Sainte, Badell Edgar, Michaud Céline, Blaizot Romain, Demar Magalie, Carvalho Luisiane, Carod Jean François, Andrieu Audrey, Djossou Félix, Toubiana Julie, Epelboin Loic, Brisse Sylvain
Аннотация
Human infections with Corynebacterium diphtheriae species complex (CdSC) bacteria were rare in French Guiana until 2016, when the number of cases diagnosed increased. We conducted an epidemiologic, multicenter, retrospective study of all human CdSC infections diagnosed in French Guiana during January 1, 2016-December 31, 2021. A total of 64 infectious episodes were observed in 60 patients; 61 infections were caused by C. diphtheriae and 3 by C. ulcerans. Estimated incidence increased from 0.7 cases/100,000 population in 2016 to 7.7 cases/100,000 population in 2021. The mean patient age was 30.4 (+23.7) years, and male-to-female ratio was 1.7:1 (38/22). Of the 61 C. diphtheriae isolates, 5 tested positive for the diphtheria toxin gene, and all results were negative by Elek test; 95% (61/64) of cases were cutaneous, including the C. ulcerans cases. The increase in reported human infections underscores the need to raise awareness among frontline healthcare practitioners to improve prevention.