Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada's Sentinel Physician Surveillance Network, January 2015.

AIM: To evaluate the effectiveness of different methods for segmenting tumor regions of interest in building prediction models for the World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade of clear cell renal cell carcinoma (ccRCC).

MATERIALS AND

METHODS

This retrospective single-center study analyzed computed tomography (CT) images of 405 patients (training/test cohort, 324/81) with pathologically confirmed ccRCC. Two methods were used for tumor segmentation: (1) automatic segmentation: the nnU-Net model, trained on the public KiTS19 dataset, and (2) manual segmentation. Radiomics features were extracted and selected from both automatically and manually segmented images. Support vector machine (SVM) and K-nearest neighbors were used to construct pathological grade prediction models. The segmentation accuracies of nnU-Net and manual annotation were compared. The receiver operating characteristic curve, area under the curve (AUC), accuracy, sensitivity, and specificity were used to evaluate diagnostic performance. The DeLong test was used to assess the differences between the models.

RESULTS

The average Dice similarity coefficient was 0.842 ± 0.149. Automatic segmentation was time-efficient. A total of 1,834 features were extracted from each tumor. The AutoSeg-SVM model with nine features achieved the highest diagnostic performance, with an AUC value of 0.865 (0.726-1.000), an accuracy of 79.0%, sensitivity of 85.7%, and specificity of 77.6%. Both models in the automatic segmentation group showed comparable or slightly better performance than those in the manual segmentation group, although the differences were not statistically significant.

CONCLUSIONS

The nnU-Net automatic segmentation provided diagnostic efficacy comparable to manual segmentation in preoperative WHO/ISUP grade prediction for ccRCC. It significantly reduced the time required for lesion segmentation and improved workflow efficiency.