Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia · 2016
[Correlation between clinical and laboratory criteria of suspected Hantavirus cases and the results of the reference diagnostic technique].
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Navarrete Maritza, Hott Melissa, Caroca Jorge, Leyton Luis, Venegas Nadialett, Ismail Kissy, Saavedra Farides, Otth Carola
Аннотация
BACKGROUND: Currently in Chile, due to the frequent clinical suspicion of Hantavirus disease and the high public health impact that this causes, it is necessary to strengthen the criteria for clinical and epidemiological suspicion in the health team.
OBJECTIVE: To analyze the information contained in the reports of suspected Hantavirus infection versus the confirmatory diagnosis with the reference technique, IgM capture ELISA anti-hantavirus. Material andMethods: Correlation between the information provided in notifications versus the result of confirmation was analyzed by calculating diagnostic accuracy.
RESULTS: 3.4% of 1,566 patients studied (53 cases) was confirmed as SCPH. 58.6% of the analyzed notifications was incomplete. The percentage of positivity of the reference technique associated with fever, myalgia and headache was 80-85%. The presence of immunoblasts (> 10%) showed 25% sensitivity, 98% specificity, 37% PPV, 97% NPV. Thrombocytopenia exhibited 98% sensitivity, 74% specificity, 16% PPV, 100% NPV.
CONCLUSION: It is necessary to reinforce the importance of comprehensive data reporting at the health system level. The presence of thrombocytopenia and immunoblasts (> 10%) is highly sensitive and specific, respectively, for detecting patients with SCPH. There is a need to develop training programs in order to optimize the suspicion of Hantavirus infection and appropriate use of health resources.
OBJECTIVE: To analyze the information contained in the reports of suspected Hantavirus infection versus the confirmatory diagnosis with the reference technique, IgM capture ELISA anti-hantavirus. Material andMethods: Correlation between the information provided in notifications versus the result of confirmation was analyzed by calculating diagnostic accuracy.
RESULTS: 3.4% of 1,566 patients studied (53 cases) was confirmed as SCPH. 58.6% of the analyzed notifications was incomplete. The percentage of positivity of the reference technique associated with fever, myalgia and headache was 80-85%. The presence of immunoblasts (> 10%) showed 25% sensitivity, 98% specificity, 37% PPV, 97% NPV. Thrombocytopenia exhibited 98% sensitivity, 74% specificity, 16% PPV, 100% NPV.
CONCLUSION: It is necessary to reinforce the importance of comprehensive data reporting at the health system level. The presence of thrombocytopenia and immunoblasts (> 10%) is highly sensitive and specific, respectively, for detecting patients with SCPH. There is a need to develop training programs in order to optimize the suspicion of Hantavirus infection and appropriate use of health resources.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntibodies, ViralChildChild, PreschoolChileDisease NotificationEnzyme-Linked Immunosorbent AssayFemaleHantaan virusHantavirus Pulmonary SyndromeHemorrhagic Fever with Renal SyndromeHumansImmunoglobulin MInfantMaleMiddle AgedReference StandardsReference ValuesSensitivity and SpecificitySeroepidemiologic StudiesSerologic TestsThrombocytopeniaYoung Adult