International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2008
Childhood brucellosis in Jordan: prevalence and analysis of risk factors.
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Al-Majali Ahmad M, Shorman Mahmoud
Аннотация
OBJECTIVES: To investigate the seroprevalence of childhood brucellosis in Jordan and to elucidate risk factors associated with seropositivity to Brucella.
METHODS: Between January 2001 and October 2006, a cross-sectional study of children aged < or = 15 years was conducted; a total of 1282 serum samples were collected. Serum samples were analyzed for the presence of antibodies to Brucella antigens using the Rose Bengal plate test (RBPT) and a direct enzyme-linked immunosorbent assay (ELISA). Risk factors associated with seropositivity to Brucella antigens were identified by constructing a multivariate logistic regression model.
RESULTS: Of the 1282 serum samples tested, 119 (9.3%) were positive by both RBPT and ELISA tests. When adjusted for the sensitivities and specificities of the two tests, the true seroprevalence was 11.6%. The seroprevalence of Brucella antibodies in Ma'an and Mafraq governorates was significantly higher than in the other governorates. The logistic regression model identified male gender (OR 2.5, 95% CI 1.4, 4.1), age older than 10 years (OR 1.8, 95% CI 1.1, 3.9), living in a village (OR 2.0, 95% CI 1.3, 2.9), and assisting in raising small ruminants (OR 1.6, 95% CI 1.1, 2.6) as risk factors for childhood Brucella seropositivity in Jordan.
CONCLUSION: This study documents the importance of brucellosis in children and further emphasizes the role of small ruminants as an important source for human infection.
METHODS: Between January 2001 and October 2006, a cross-sectional study of children aged < or = 15 years was conducted; a total of 1282 serum samples were collected. Serum samples were analyzed for the presence of antibodies to Brucella antigens using the Rose Bengal plate test (RBPT) and a direct enzyme-linked immunosorbent assay (ELISA). Risk factors associated with seropositivity to Brucella antigens were identified by constructing a multivariate logistic regression model.
RESULTS: Of the 1282 serum samples tested, 119 (9.3%) were positive by both RBPT and ELISA tests. When adjusted for the sensitivities and specificities of the two tests, the true seroprevalence was 11.6%. The seroprevalence of Brucella antibodies in Ma'an and Mafraq governorates was significantly higher than in the other governorates. The logistic regression model identified male gender (OR 2.5, 95% CI 1.4, 4.1), age older than 10 years (OR 1.8, 95% CI 1.1, 3.9), living in a village (OR 2.0, 95% CI 1.3, 2.9), and assisting in raising small ruminants (OR 1.6, 95% CI 1.1, 2.6) as risk factors for childhood Brucella seropositivity in Jordan.
CONCLUSION: This study documents the importance of brucellosis in children and further emphasizes the role of small ruminants as an important source for human infection.
Предметные рубрики MeSH
AdolescentAnimal HusbandryAnimalsAnimals, DomesticAntibodies, BacterialBrucellaBrucellosisChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansJordanLogistic ModelsMalePrevalenceRisk FactorsRose BengalSensitivity and SpecificitySeroepidemiologic StudiesSerologic Tests