Cell metabolism · 2016
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.
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Raffan Eleanor, Dennis Rowena J, O'Donovan Conor J, Becker Julia M, Scott Robert A, Smith Stephen P, Withers David J, Wood Claire J, Conci Elena, Clements Dylan N, Summers Kim M, German Alexander J, Mellersh Cathryn S, Arendt Maja L, Iyemere Valentine P, Withers Elaine, Söder Josefin, Wernersson Sara, Andersson Göran, Lindblad-Toh Kerstin, Yeo Giles S H, O'Rahilly Stephen
Аннотация
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.