Communications biology · 2024
A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ito Shuji, Takuwa Hiroshi, Kakehi Saori, Someya Yuki, Kaga Hideyoshi, Kumahashi Nobuyuki, Kuwata Suguru, Wakatsuki Takuya, Kadowaki Masaru, Yamamoto Soichiro, Abe Takafumi, Takeda Miwako, Ishikawa Yuki, Liu Xiaoxi, Otomo Nao, Suetsugu Hiroyuki, Koike Yoshinao, Hikino Keiko, Tomizuka Kohei, Momozawa Yukihide, Ozaki Kouichi, Isomura Minoru, Nabika Toru, Kaneko Haruka, Ishijima Muneaki, Kawamori Ryuzo, Watada Hirotaka, Tamura Yoshifumi, Uchio Yuji, Ikegawa Shiro, Terao Chikashi
Аннотация
Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10-8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia.