Nature aging · 2024
Human skeletal muscle aging atlas.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Kedlian Veronika R, Wang Yaning, Liu Tianliang, Chen Xiaoping, Bolt Liam, Tudor Catherine, Shen Zhuojian, Fasouli Eirini S, Prigmore Elena, Kleshchevnikov Vitalii, Pett Jan Patrick, Li Tong, Lawrence John E G, Perera Shani, Prete Martin, Huang Ni, Guo Qin, Zeng Xinrui, Yang Lu, Polański Krzysztof, Chipampe Nana-Jane, Dabrowska Monika, Li Xiaobo, Bayraktar Omer Ali, Patel Minal, Kumasaka Natsuhiko, Mahbubani Krishnaa T, Xiang Andy Peng, Meyer Kerstin B, Saeb-Parsy Kourosh, Teichmann Sarah A, Zhang Hongbo
Аннотация
Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes. Our atlas also highlights an expansion of nuclei associated with the neuromuscular junction, which may reflect re-innervation, and outlines how the loss of fast-twitch myofibers is mitigated through regeneration and upregulation of fast-type markers in slow-twitch myofibers with age. Furthermore, we document the function of aging muscle microenvironment in immune cell attraction. Overall, we present a comprehensive human skeletal muscle aging resource ( https://www.muscleageingcellatlas.org/ ) together with an in-house mouse muscle atlas to study common features of muscle aging across species.