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DOI 10.1016/j.tem.2024.01.004

Медицинская библиотека · Trends in endocrinology and metabolism: TEM · 2024

A perspective on muscle phenotyping in musculoskeletal research.

Foessl Ines, Ackert-Bicknell Cheryl L, Kague Erika, Laskou Faidra, Jakob Franz, Karasik David, Obermayer-Pietsch Barbara, Co-authors, Alonso Nerea, Bjørnerem Åshild, Brandi Maria Luisa, Busse Björn, Calado Ângelo, Cebi Alper Han, Christou Maria, Curran Kathleen M, Hald Jannie Dahl, Semeraro Maria Donatella, Douni Eleni, Duncan Emma L, Duran Ivan, Formosa Melissa M, Gabet Yankel, Ghatan Samuel, Gkitakou Artemis, Hassler Eva Maria, Högler Wolfgang, Heino Terhi J, Hendrickx Gretl, Khashayar Patricia, Kiel Douglas P, Koromani Fjorda, Langdahl Bente, Lopes Philippe, Mäkitie Outi, Maurizi Antonio, Medina-Gomez Carolina, Ntzani Evangelia, Ohlsson Claes, Prijatelj Vid, Rabionet Raquel, Reppe Sjur, Rivadeneira Fernando, Roshchupkin Gennady, Sharma Neha, Søe Kent, Styrkarsdottir Unnur, Szulc Pavel, Teti Anna, Tobias Jon, Valjevac Amina, van de Peppel Jeroen, van der Eerden Bram, van Rietbergen Bert, Zekic Tatjana, Zillikens M Carola

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Аннотация

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

Для цитирования: Foessl Ines, Ackert-Bicknell Cheryl L, Kague Erika, Laskou Faidra, Jakob Franz, Karasik David, Obermayer-Pietsch Barbara, Co-authors, Alonso Nerea, Bjørnerem Åshild, Brandi Maria Luisa, Busse Björn, Calado Ângelo, Cebi Alper Han, Christou Maria, Curran Kathleen M, Hald Jannie Dahl, Semeraro Maria Donatella, Douni Eleni, Duncan Emma L, Duran Ivan, Formosa Melissa M, Gabet Yankel, Ghatan Samuel, Gkitakou Artemis, Hassler Eva Maria, Högler Wolfgang, Heino Terhi J, Hendrickx Gretl, Khashayar Patricia, Kiel Douglas P, Koromani Fjorda, Langdahl Bente, Lopes Philippe, Mäkitie Outi, Maurizi Antonio, Medina-Gomez Carolina, Ntzani Evangelia, Ohlsson Claes, Prijatelj Vid, Rabionet Raquel, Reppe Sjur, Rivadeneira Fernando, Roshchupkin Gennady, Sharma Neha, Søe Kent, Styrkarsdottir Unnur, Szulc Pavel, Teti Anna, Tobias Jon, Valjevac Amina, van de Peppel Jeroen, van der Eerden Bram, van Rietbergen Bert, Zekic Tatjana, Zillikens M Carola. A perspective on muscle phenotyping in musculoskeletal research.. Trends in endocrinology and metabolism: TEM. 2024. DOI: 10.1016/j.tem.2024.01.004.

Предметные рубрики MeSH

AnimalsHumansPhenotypeMuscle, SkeletalZebrafishMiceSarcopeniaMusculoskeletal DiseasesOsteoporosis
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