American journal of physiology. Heart and circulatory physiology · 2016
Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia.
СтатьяНазвание и аннотация: Перевод в очереди
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Lee Reggie H, Couto E Silva Alexandre, Lerner Francesca M, Wilkins Carl S, Valido Stephen E, Klein Daniel D, Wu Celeste Y, Neumann Jake T, Della-Morte David, Koslow Stephen H, Minagar Alireza, Lin Hung Wen
Аннотация
UNLABELLED: Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism(s) of the sympathetic nervous system during ischemia.
NEW & NOTEWORTHY: Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.
NEW & NOTEWORTHY: Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.