Peyronie's disease and systemic lupus erythematosus syndrome associated with metoprolol administration: a case report.

Peyronie's disease (induratio penis plastica) and a syndrome resembling systemic lupus erythematosus (S.L.E.) contemporaneously developed in a 50-year-old man six months after initiation of treatment with metoprolol. In view of the improvement in symptoms and signs on withdrawal of metoprolol, it seems likely that the drug was responsible for both these conditions. Peyronie's disease has been observed in relation to treatment with other adrenergic blocking agents, including practolol, and the S.L.E. syndrome is thought to be a possible untoward effect of practolol therapy. The relationship between practolol and sclerosing conditions elsewhere in the body is well recognized and an immunological basis for the fibrosis has been suggested. Similarly, the possibility is raised that Peyronie's disease may be in this case a particular expression of the auto immune disorder induced by metoprolol administration.