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Войти в исследования Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2016
Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Stahl Mirjam, Holfelder Christian, Kneppo Carolin, Kieser Meinhard, Kasperk Christian, Schoenau Eckhard, Sommerburg Olaf, Tönshoff Burkhard
Аннотация
BACKGROUND: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined.
METHODS: In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated.
RESULTS: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%).
CONCLUSIONS: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.
METHODS: In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated.
RESULTS: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%).
CONCLUSIONS: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.