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Войти в исследования Ocular immunology and inflammation · 2025
Overlap Syndrome of Cogan's and Tubulointerstitial Nephritis and Uveitis (TINU) in a Case with Uveitis, Hearing Loss, and Kidney Involvement.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Pinar Eymen, Demirbas Kaan, Yilmaz Yetkin Zeki, Ucar Didar, Sahin Sezgin, Kasapcopur Ozgur
Аннотация
PURPOSE: Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disorder characterized by concurrent renal and ocular inflammation. Auditory features resembling Cogan's syndrome have been reported in TINU, though the nature of this overlap remains poorly understood. Here, we report a pediatric case of atypical Cogan syndrome to contribute to the growing literature on this unusual clinical association.
MATERIALS AND METHODS: Description of a case report and overview of the current literature.
RESULTS: 12-year-old female with TINU syndrome characterized by bilateral anterior uveitis and renal dysfunction, later suffered from a sudden-onset unilateral sensorineural hearing loss (SNHL). After a course of immunosuppressive therapy, only auditory symptoms persisted. This case highlights the phenotypic variability of TINU syndrome with atypical Cogan features, emphasizing the need for early recognition, multidisciplinary management, and further research to elucidate shared pathophysiological mechanisms.
CONCLUSIONS: Auditory manifestations in TINU syndrome reveal phenotypic diversity and possible overlap with Cogan syndrome, requiring early diagnosis and multidisciplinary management.
MATERIALS AND METHODS: Description of a case report and overview of the current literature.
RESULTS: 12-year-old female with TINU syndrome characterized by bilateral anterior uveitis and renal dysfunction, later suffered from a sudden-onset unilateral sensorineural hearing loss (SNHL). After a course of immunosuppressive therapy, only auditory symptoms persisted. This case highlights the phenotypic variability of TINU syndrome with atypical Cogan features, emphasizing the need for early recognition, multidisciplinary management, and further research to elucidate shared pathophysiological mechanisms.
CONCLUSIONS: Auditory manifestations in TINU syndrome reveal phenotypic diversity and possible overlap with Cogan syndrome, requiring early diagnosis and multidisciplinary management.