International journal of cardiology · 2026
Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.
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Zhou Zhongqin, Ye Pengfei, Wang Chuan, Azhe Shiganmo, Hu Lei, Zhang Nanjun, Peng Shengkun, Deng Xinrui, Zhu Yaoji, Ye Lu, Qin Haodong, Zhou Kaiyu, Guo Yingkun, Hu Xihong, Wen Lingyi
Аннотация
BACKGROUND: Kawasaki disease (KD) is associated with various myocardial injuries, including myocardial perfusion abnormality. This study aims to assess the distribution of myocardial perfusion abnormality in patients with KD and explore their relationships with left ventricular (LV) remodeling.
METHODS: This prospective single-center study enrolled children with KD who underwent fully quantitative CMR rest perfusion. Myocardial blood flow (MBF) was measured and corrected based on the heart rate-blood pressure product (MBFcor). Statistical analyses included ANOVA, Pearson correlation and multivariate linear regression.
RESULTS: Eighty-seven patients with KD (mean age, 7.5 ± 2.2 years) and 33 age- and sex-matched controls (mean age, 8.2 ± 2.8 years) were included. Global MBFcor was lower in patients than in controls, especially among patients during the acute phase. Subgroup analysis showed that patients with Z score ≥ 5 had significant decreases in global MBFcor, as well as regional MBFcor in the territories of the left anterior descending artery (LAD) and left circumflex artery (LCX) (p < 0.05 for all). Global MBFcor and regional MBFcor in the territories of the LAD and LCX were correlated with Z score among patients with KD. Covariate-adjusted multivariable regression analyses demonstrated that Z score and the acute phase were independently associated with global MBFcor. Furthermore, global MBFcor was negatively associated with increased LV mass index.
CONCLUSIONS: Fully quantitative CMR rest first-pass perfusion revealed decreased myocardial perfusion in children with KD. Z score and the acute phase were independently associated with decreased myocardial perfusion; decreased MBFcor was associated with LV mass index.
METHODS: This prospective single-center study enrolled children with KD who underwent fully quantitative CMR rest perfusion. Myocardial blood flow (MBF) was measured and corrected based on the heart rate-blood pressure product (MBFcor). Statistical analyses included ANOVA, Pearson correlation and multivariate linear regression.
RESULTS: Eighty-seven patients with KD (mean age, 7.5 ± 2.2 years) and 33 age- and sex-matched controls (mean age, 8.2 ± 2.8 years) were included. Global MBFcor was lower in patients than in controls, especially among patients during the acute phase. Subgroup analysis showed that patients with Z score ≥ 5 had significant decreases in global MBFcor, as well as regional MBFcor in the territories of the left anterior descending artery (LAD) and left circumflex artery (LCX) (p < 0.05 for all). Global MBFcor and regional MBFcor in the territories of the LAD and LCX were correlated with Z score among patients with KD. Covariate-adjusted multivariable regression analyses demonstrated that Z score and the acute phase were independently associated with global MBFcor. Furthermore, global MBFcor was negatively associated with increased LV mass index.
CONCLUSIONS: Fully quantitative CMR rest first-pass perfusion revealed decreased myocardial perfusion in children with KD. Z score and the acute phase were independently associated with decreased myocardial perfusion; decreased MBFcor was associated with LV mass index.