Ceftriaxon in treatment of bacterial meningitis.

The authors tested cephalosporin antibiotic of the 3rd generation--Ceftriaxon--in treatment of bacterial meningitis. After studying the infiltration of the antibiotic into the cerebrospinal fluid in 13 patients with parotitic meningoencephalitis, the authors treated 15 patients with bacterial meningitis. Ceftriaxon has been applied in 100 mg/kg in two doses i.v. The research antibiotic levels in cerebrospinal fluid varied from 10 to 30% of sera levels and were much higher than MIC for pathogens isolated from liquor. The treatment effects were very good the dropping of temperature followed on the 3-4 day, the 5-6, day under 100/3. The side effects showed a short time increasing of transaminases and diarrhoea. After completing the treatment normalisation occurred quickly. Other side effects have not occurred. The authors can state, Ceftriaxon in treatment of bacterial meningitis is a highly effective antibiotic.