Genomics · 2025
Genomic insights into the potency and functional roles of Lactobacillus species in term and preterm births.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Talukdar Daizee, Raju Yodhaanjali Jinnenahalli, Jana Pradipta, Sharma Komal, Babele Prabhakar, Kothidar Akansha, Ahrodia Taruna, Narendrakumar Lekshmi, Shyam K Ramani, Singh Upma, Tanwar Subhash, Harle Sachin, Chaudhuri Susmita, Raghavan Sreevatsan, Wadhwa Nitya, Mukherjee Souvik, Bhatnagar Shinjini, Das Bhabatosh, GARBH-Ini study group
Аннотация
The vaginal microbiome, typically dominated by Lactobacillus species, plays a key role in reducing the risk of preterm birth (PTB) by protecting against infections. In this study, we sequenced 133 Lactobacillus genomes isolated from the reproductive tracts of pregnant Indian women. Genomic analysis identified genes linked to pathogen resistance and anti-inflammatory functions. Further proteome analysis of cell-free supernatant revealed antimicrobial properties, including lysin and bacteriocin, while antibacterial tests confirmed their ability to inhibit reproductive tract pathogens. These findings suggest that Lactobacillus strains protect against harmful microbes, potentially reducing infection risks and PTB. This Lactobacillus consortium holds promise for developing biotherapeutics aimed at improving maternal health.