The Nigerian postgraduate medical journal · 2013
Bacterial isolates from cerebrospinal fluid of children with suspected acute meningitis in a Nigerian tertiary hospital.
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Nwadioha S I, Nwokedi E O P, Onwuezube I, Egesie J O, Kashibu E
Аннотация
AIMS AND OBJECTIVES: To determine the common aetiolog of acute bacterial meningitis in children and their antibiotic susceptibility pattern.
MATERIALS AND METHODS: A retrospective study with a review of cerebrospinal fluid culture reports of paediatric patients aged 0-15 years, suspected of acute meningitis in the Medical Microbiology Department of Aminu Kano Teaching Hospital, Kano, Nigeria from October 2006 to October 2009 from October 2006 to October 2009.
RESULTS: A positive culture bacterial isolation rate of 3.3% (n=50/1500) with prevalence of Streptococcus pneumoniae (24%), Neisseria meningitidis (22%), Escherichia coli (16%), Haemophilus influenzae (14%), Group B streptococci (8%) and Enterococci (8%) which were susceptible to ceftriaxone (96%), cefotaxime (95%) and ciprofloxacin (93%) across the bacterial isolates. Neonates were 55% (n=6.8/12.4) most at risk.
CONCLUSION: Neonates are the most at risk of acute bacterial meningitis. In the absence of antibiotic susceptibility report, ceftriaxone should be considered as a first choice reliable antibiotic for empirical treatment of meningitis in children, in this environment.
MATERIALS AND METHODS: A retrospective study with a review of cerebrospinal fluid culture reports of paediatric patients aged 0-15 years, suspected of acute meningitis in the Medical Microbiology Department of Aminu Kano Teaching Hospital, Kano, Nigeria from October 2006 to October 2009 from October 2006 to October 2009.
RESULTS: A positive culture bacterial isolation rate of 3.3% (n=50/1500) with prevalence of Streptococcus pneumoniae (24%), Neisseria meningitidis (22%), Escherichia coli (16%), Haemophilus influenzae (14%), Group B streptococci (8%) and Enterococci (8%) which were susceptible to ceftriaxone (96%), cefotaxime (95%) and ciprofloxacin (93%) across the bacterial isolates. Neonates were 55% (n=6.8/12.4) most at risk.
CONCLUSION: Neonates are the most at risk of acute bacterial meningitis. In the absence of antibiotic susceptibility report, ceftriaxone should be considered as a first choice reliable antibiotic for empirical treatment of meningitis in children, in this environment.
Предметные рубрики MeSH
AdolescentAnti-Bacterial AgentsCefotaximeCeftriaxoneCerebrospinal FluidChildChild, PreschoolCiprofloxacinEnterococcusEscherichia coliHaemophilus influenzaeHumansInfantInfant, NewbornMeningitis, BacterialMeningitis, Escherichia coliMeningitis, HaemophilusMeningitis, MeningococcalMeningitis, PneumococcalMicrobial Sensitivity TestsNigeriaRetrospective StudiesStreptococcus agalactiaeTertiary Care Centers