Successful treatment of chronic spontaneous urticaria and bladder pain syndrome with montelukast and/or omalizumab: a case report.

BACKGROUND

Bladder pain syndrome (BPS) is a chronic condition characterized by pelvic pain, frequency, and urgency lasting more than 6 months without a urinary tract infection. It is a devastating condition that affects both sexes and is often confused with other conditions that cause pelvic pain. Diagnosis is difficult, and effective treatment options are limited.

CASE PRESENTATION: In this article, I present a 59 year-old Turkish male patient with chronic spontaneous urticaria with typical clinical symptoms of bladder pain syndrome. Common etiologies that could cause increased urinary frequency, urgency or nocturia, urinary tract infection, and overactive bladder were excluded.

CONCLUSION

The patient's symptoms improved significantly with omalizumab and montelukast. This case not only provides new insight into the management of BPS, but also highlights the potential roles of mast cell-mediated mechanisms in the etiology and treatment of this complex condition.