Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes.
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Tang Xin, Ahmed Salahuddin, Ahmed Farzana Bashir, Albrecht Vincent, Brennsteiner Vincenth, Chang Alan Lee, Chowdhury Nabidul Haque, Deb Saikat, Gormley Matthew, Hasan Tarik, Kamulaza Leah, Khalid Javairia, Khan Waqasuddin, Khanam Rasheda, Kshetrapal Pallavi, Luo Hanqi, Maiti Tushar K, Maitra Arindam, Mannan Mohammad Mohsin, Mueller-Reif Johannes, Mulenga Clyde, Nisar Imran, Pervin Jesmin, Pokaprakarn Teeranan, Price Joni, Qazi Muhammad F, Rittenhouse Katelyn, Sebastiao Yuri, Sindano Ntazana, Sinha Tulika, Sopory Shailaja, Steger Medini, Thiruvengadam Ramachandran, Wadhwa Nitya, Xue Lei, Aghaeepour Nima, Baqui Abdullah H, Bhatnagar Shinjini, Fisher Susan, Fox Melissa, Hampel Daniela, Kasaro Margaret, Mann Matthias, Rahman Anisur, Sazawal Sunil, Shenhav Liat, Stringer Jeffrey Sa, Zhang Ge, Jehan Fyezah, De Paris Kristina
Аннотация
METHODS: The combined MOMI cohort includes 24 321 pregnant women, a rich biorepository, and paired socioeconomic and clinical data. Considering the multifactorial aetiologies and molecular drivers of APOs, we applied an integrative multi-omics (genomics, metabolomics, proteomics, nutrient testing) approach to identify site-specific and cohort-wide signatures linked to distinct APOs.
CONCLUSIONS: This protocol summarises the MOMI study design, sample and data collection methods, data harmonisation, and the various analytics platforms, and discusses potential outcomes for enhanced clinical care and novel diagnostic and therapeutic tools.