Substantiation of attention around antioxidants of plant origin for use in complex pharmacotherapy of diseases of the oral cavity.

As is known, phytochemical substances can play an important role in maintaining homeostasis and the prevention of chronic diseases, including diseases of the mouth. The most popular are polyphenols, which are very common in fruits, vegetables, beverages, cereals. There are data on their polyvalent pharmacological activity: antioxidant, antiinflammatory, detoxifying properties, antihypoxic, immunocorrective action, the ability to improve the endothelial function, etc. Quercetin (3,3', 4', 5,7-pentahydroxyflavone) is the main flavonoid in our daily diet. Of particular interest in the therapeutic activity of quercetin is its use in dental practice, in particular in the treatment of one of the leading problems - periodontal disease. Moreover, in modern pharmacotherapy, the strategic goals define the use of combination drugs, which is explained by the limited effectiveness of classical (traditional) monotherapy. Despite the good characteristics of quercetin, like many flavonoids, it is characterized by reduced bioavailability due to limited absorption. Therefore, increasing the bioavailability of quercetin is one of the most important goals of modern research. A modern pharmacy has proposed a number of dosage forms that improve bioavailability, including dental films or chips, which are intended for topical use and belong to the transdermal therapeutic systems and are applied by application to the mucous membrane of the mouth and periodontium. Based on the literature, we can predict that quercetin preparations water-soluble form and liposomal form, will be effective in dental practice, in particular in the treatment of periodontitis, affecting the main pathogenetic links. It has been proven that quercetin has an organ protective effect, increases the effectiveness of basic therapy, promotes a positive clinical effect, improves the course of the disease regardless of the severity, reduces the risk of complications. Moreover, quercetin has no toxicity and cumulative effect stimulates the activity of the body's enzymatic systems.