International angiology : a journal of the International Union of Angiology · 2026
Impact of previous skin hydration on postsclerotherapy hyperpigmentation: a prospective, randomized, comparative study (SKINCARE Study).
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Borges Firmo Mariana, Neves Samantha, Portugal Maria F, Santana DA Silva Viviane, Firmo Emanuel, Leal Isabela, Ribeiro DE Azevedo Taina, Rodrigues Santiago Fabricio, Hueb Bernardi Walkiria, Caffaro Roberto A, Ramacciotti Eduardo
Аннотация
BACKGROUND: Postsclerotherapy hyperpigmentation (PSH) is a frequent and distressing complication. It is a cosmetic concern in aesthetic phlebology, with limited prospective efficacy/safety data. Skin hydration with moisturizer strengthens the skin barrier and may potentially prevent postsclerotherapy hyperpigmentation.
METHODS: This prospective, randomized, comparative study included 55 adult patients with reticular veins and telangiectasias. Patients were randomized to receive a daily moisturizer for 30 days before sclerotherapy or to no hydration. All participants underwent a single session of polidocanol 0.5% sclerotherapy. The primary efficacy outcome was moisturization's ability to prevent PSH, as evaluated by blinded evaluators using photos taken before and after procedures. Secondary outcomes included patient-reported outcomes assessed using the VEINES-QoL/Sym questionnaire.
RESULTS: Both groups experienced hyperpigmentation. PSH appeared in fewer patients who received hydration (44% vs. 57%, P=0.423), with no statistically significant difference. No skin alterations occurred at any time point. Nine patients (90%) rated the results as "very good" or "excellent".
CONCLUSIONS: In this randomized, double-arm, prospective, pilot study, the use of moisturizer 30 days before polidocanol 0.5% sclerotherapy did not reduce PSH.
METHODS: This prospective, randomized, comparative study included 55 adult patients with reticular veins and telangiectasias. Patients were randomized to receive a daily moisturizer for 30 days before sclerotherapy or to no hydration. All participants underwent a single session of polidocanol 0.5% sclerotherapy. The primary efficacy outcome was moisturization's ability to prevent PSH, as evaluated by blinded evaluators using photos taken before and after procedures. Secondary outcomes included patient-reported outcomes assessed using the VEINES-QoL/Sym questionnaire.
RESULTS: Both groups experienced hyperpigmentation. PSH appeared in fewer patients who received hydration (44% vs. 57%, P=0.423), with no statistically significant difference. No skin alterations occurred at any time point. Nine patients (90%) rated the results as "very good" or "excellent".
CONCLUSIONS: In this randomized, double-arm, prospective, pilot study, the use of moisturizer 30 days before polidocanol 0.5% sclerotherapy did not reduce PSH.