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DOI 10.1002/alz.71351

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026

Imaging the later-life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI.

Groh Jenna R, Miner Annalise E, Alshikho Mohamad J, Farris Chad, Cui Anna, Pettway Erika, Labonte Jacob, Mosaheb Sydney, Tripodis Yorghos, Adler Charles H, Balcer Laura J, Bernick Charles, Cantu Robert C, Coleman Michael J, Dodick David W, Ashton Nicholas J, Zetterberg Henrik, Blennow Kaj, Peskind Elaine R, Nowinski Christopher, Ly Monica, Altaras Caroline, Lenio Steven, Rabinovici Gil D, Asken Breton, Rosen Howard, Cobigo Yann, Blusztajn Jan Krzysztof, Budson Andrew E, Turk Katherine, Qiu Wei Qiao, Goldstein Lee, Martin Brett, Palmisano Joseph N, Dixon Diane, Schneider Greta, Steinberg Eric G, Su Yi, Protas Hillary, Pasternak Ofer, Koerte Inga, Bouix Sylvain, Cummings Jeffrey L, Reiman Eric M, Shenton Martha E, Stern Robert A, McKee Ann C, Stein Thor D, Brickman Adam M, Mez Jesse, Alosco Michael L

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Аннотация

INTRODUCTION

Repetitive head impacts (RHI) from contact sports may cause a unique pattern of white matter hyperintensities (WMH) on T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), termed RHI-associated WMH (RHI-WMH). These lesions are punctate, circular, and located at the gray-white matter boundary, an area vulnerable to trauma-related damage.

METHODS

We investigated the association of RHI with these lesions in two aging cohorts: (1) former American football players versus asymptomatic unexposed men and (2) individuals with RHI from various contact sports versus non-RHI participants. RHI-WMH were assessed using visual ratings and a novel automated quantification pipeline.

RESULTS

Individuals with RHI had greater RHI-WMH by both detection methods in both cohorts. RHI-WMH were associated with plasma neurofilament light and p-tau231, and flortaucipir positron emission tomography (PET) uptake.

DISCUSSION: RHI-WMH may represent a new supportive biomarker for the detection of RHI-related neuropathologies later in life.

Для цитирования: Groh Jenna R, Miner Annalise E, Alshikho Mohamad J, Farris Chad, Cui Anna, Pettway Erika, Labonte Jacob, Mosaheb Sydney, Tripodis Yorghos, Adler Charles H, Balcer Laura J, Bernick Charles, Cantu Robert C, Coleman Michael J, Dodick David W, Ashton Nicholas J, Zetterberg Henrik, Blennow Kaj, Peskind Elaine R, Nowinski Christopher, Ly Monica, Altaras Caroline, Lenio Steven, Rabinovici Gil D, Asken Breton, Rosen Howard, Cobigo Yann, Blusztajn Jan Krzysztof, Budson Andrew E, Turk Katherine, Qiu Wei Qiao, Goldstein Lee, Martin Brett, Palmisano Joseph N, Dixon Diane, Schneider Greta, Steinberg Eric G, Su Yi, Protas Hillary, Pasternak Ofer, Koerte Inga, Bouix Sylvain, Cummings Jeffrey L, Reiman Eric M, Shenton Martha E, Stern Robert A, McKee Ann C, Stein Thor D, Brickman Adam M, Mez Jesse, Alosco Michael L. Imaging the later-life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. DOI: 10.1002/alz.71351.

Предметные рубрики MeSH

HumansMaleMagnetic Resonance ImagingWhite MatterAgedFootballMiddle AgedPositron-Emission TomographyBrain ConcussionBrain
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