Critical care medicine · 2005
Changes in the interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Pathan Nazima, Williams E John, Oragui E Emanuelle, Stephens Alick C, Levin Michael
Аннотация
OBJECTIVE: Interleukin-6 is strongly associated with disease severity and outcome in meningococcal septicemia. It is known that interleukin-6 exerts many of its effects via the soluble interleukin-6 receptor. By facilitating the activity of interleukin-6, it is likely that alterations in the levels of soluble interleukin-6 receptor in septic shock could affect the severity of disease. We aimed to investigate changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcal septicemia and the relationship with disease severity.
DESIGN: Laboratory investigation of interleukin-6 and soluble interleukin-6 receptor levels in children with meningococcal disease.
SETTING: University hospital and laboratories.
SUBJECTS: Children with severe meningococcal disease requiring intensive care.
INTERVENTIONS: Blood samples obtained on admission to the intensive care unit were analyzed for interleukin-6 and soluble interleukin-6 receptor levels. Levels were also serially measured for up to 48 hrs in a subset of patients.
MEASUREMENTS AND MAIN RESULTS: Cytokine levels were measured by enzyme-linked immunosorbent assay using mouse monoclonal antihuman antibodies. Acute meningococcemia is associated with a reduction in soluble interleukin-6 receptor levels in proportion to disease severity and is inversely related to interleukin-6 levels. Soluble interleukin-6 receptor returns to levels seen in normal donors following recovery from meningococcal septicemia.
CONCLUSIONS: Changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcemia may affect the severity and progression of multiple organ failure. Interventions to modulate this axis may improve outcome from meningococcal septic shock.
DESIGN: Laboratory investigation of interleukin-6 and soluble interleukin-6 receptor levels in children with meningococcal disease.
SETTING: University hospital and laboratories.
SUBJECTS: Children with severe meningococcal disease requiring intensive care.
INTERVENTIONS: Blood samples obtained on admission to the intensive care unit were analyzed for interleukin-6 and soluble interleukin-6 receptor levels. Levels were also serially measured for up to 48 hrs in a subset of patients.
MEASUREMENTS AND MAIN RESULTS: Cytokine levels were measured by enzyme-linked immunosorbent assay using mouse monoclonal antihuman antibodies. Acute meningococcemia is associated with a reduction in soluble interleukin-6 receptor levels in proportion to disease severity and is inversely related to interleukin-6 levels. Soluble interleukin-6 receptor returns to levels seen in normal donors following recovery from meningococcal septicemia.
CONCLUSIONS: Changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcemia may affect the severity and progression of multiple organ failure. Interventions to modulate this axis may improve outcome from meningococcal septic shock.