Facilitating Genetic Testing for Perinatal Demise: Development of a Multidisciplinary Workflow.

Genetic contributors to perinatal demise are common but frequently undiagnosed due to clinical and logistical barriers. We aimed to improve access to genetic for intrauterine fetal demise (IUFD), stillbirth, and early neonatal death by developing a multidisciplinary workflow. A working group representing clinical genetics, maternal-fetal medicine, neonatology, pathology, obstetrics, palliative care, laboratories, and health information technology identified barriers and designed solutions for genetic testing in perinatal demise. Tools developed included testing algorithms, specimen collection and handling guides, documentation templates, and electronic health record integration. Case reviews and stakeholder feedback informed iterative refinement. The workflow clarified team roles, timing, and coordination across specialties. Scenario-specific algorithms for stillbirth, neonatal demise, and pediatric genetics consultations guided testing decisions. A specimen-testing matrix linked sample types with available tests and laboratories. Implementation was supported by education and centralized resources. Representative cases demonstrated improved sample collection, diagnostic yield, and family counseling through early communication and defined responsibilities. A multidisciplinary workflow improved the feasibility and consistency of genetic evaluation in perinatal demise. This model may guide other institutions seeking to implement or enhance genetic testing processes for families affected by pregnancy loss or neonatal death.