Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2025
An International Delphi-Based Study for Developing a Core Outcome Set for Hypospadias Surgery.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Leunbach Tina L, Yankovic Francisca, Springer Alexander, Wisniewski Amy, Burgu Berk, Braga Luis, Ernst Andreas, Lucas-Herald Angela, O'Toole Stuart, Ahmed S Faisal, Rawashdeh Yazan F
Аннотация
INTRODUCTION: Explicit outcomes routinely measured across the life span following hypospadias surgery, defined by a core outcome set (COS), will harmonize and overcome reporting heterogeneity.
METHODS: Age-specific outcomes identified in a literature review were presented in a three-round Delphi survey. Participants (professionals, parents, and patients) were encouraged to suggest outcomes in the first Delphi round. In subsequent rounds, participants were asked to choose and rank up to five preferred outcomes for each age. To be deemed core, an outcome needed over 70% of votes in a round.
RESULTS: Professionals were mainly paediatric urologists (rounds 1, 2, 3: n = 57 [77%], 39 [78%], 35 [81%]). The response rates from parents/patients (rounds 1, 2, 3: n = 17, 5, 3) were low. In young boys (<6 years, 10-11 years), four core outcomes were identical (voiding, fistula, re-operation, and urethral stricture). Core outcomes in boys aged 11-16 years (cosmesis, curvature, voiding, stricture, and psychosocial status) and boys >16 years (cosmesis, curvature, erection, voiding, and psychosexual development) varied more.
CONCLUSION: Outcomes to include in a COS were consistent in younger boys. A larger variety was observed in older boys and reflects less clarity on relevant outcomes.
METHODS: Age-specific outcomes identified in a literature review were presented in a three-round Delphi survey. Participants (professionals, parents, and patients) were encouraged to suggest outcomes in the first Delphi round. In subsequent rounds, participants were asked to choose and rank up to five preferred outcomes for each age. To be deemed core, an outcome needed over 70% of votes in a round.
RESULTS: Professionals were mainly paediatric urologists (rounds 1, 2, 3: n = 57 [77%], 39 [78%], 35 [81%]). The response rates from parents/patients (rounds 1, 2, 3: n = 17, 5, 3) were low. In young boys (<6 years, 10-11 years), four core outcomes were identical (voiding, fistula, re-operation, and urethral stricture). Core outcomes in boys aged 11-16 years (cosmesis, curvature, voiding, stricture, and psychosocial status) and boys >16 years (cosmesis, curvature, erection, voiding, and psychosexual development) varied more.
CONCLUSION: Outcomes to include in a COS were consistent in younger boys. A larger variety was observed in older boys and reflects less clarity on relevant outcomes.