Archives of disease in childhood. Fetal and neonatal edition · 2015
Antenatal substance misuse and smoking and newborn hypoxic challenge response.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ali Kamal, Rossor Thomas, Bhat Ravindra, Wolff Kim, Hannam Simon, Rafferty Gerrard F, Peacock Janet L, Greenough Anne
Аннотация
OBJECTIVES: Infants of smoking (S) and substance misusing (SM) mothers have an increased risk of sudden infant death syndrome. The aim of this study was to test the hypothesis that infants of SM or S mothers compared with infants of non-SM, non-smoking mothers (controls) would have a poorer ventilatory response to hypoxia, which was particularly marked in the SM infants.
DESIGN: Physiological study.
SETTING: Tertiary perinatal centre.
PATIENTS: 21 SM; 21 S and 19 control infants. Infants were assessed before maternity/neonatal unit discharge.
INTERVENTIONS: Maternal and infant urine samples were tested for cotinine, cannabinoids, opiates, amphetamines, methadone, cocaine and benzodiazepines.
MAIN OUTCOME MEASURES: During quiet sleep, the infants were switched from breathing room air to 15% oxygen and changes in minute volume were assessed.
RESULTS: The SM infants had a greater mean increase (p=0.028, p=0.034, respectively) and a greater magnitude of decline (p<0.001, p=0.018, respectively) in minute volume than the S infants and the controls. The rate of decline in minute volume was greater in the SM infants (p=0.008) and the S infants (p=0.011) compared with the controls.
CONCLUSIONS: Antenatal substance misuse and smoking affect the infant's ventilatory response to a hypoxic challenge.
DESIGN: Physiological study.
SETTING: Tertiary perinatal centre.
PATIENTS: 21 SM; 21 S and 19 control infants. Infants were assessed before maternity/neonatal unit discharge.
INTERVENTIONS: Maternal and infant urine samples were tested for cotinine, cannabinoids, opiates, amphetamines, methadone, cocaine and benzodiazepines.
MAIN OUTCOME MEASURES: During quiet sleep, the infants were switched from breathing room air to 15% oxygen and changes in minute volume were assessed.
RESULTS: The SM infants had a greater mean increase (p=0.028, p=0.034, respectively) and a greater magnitude of decline (p<0.001, p=0.018, respectively) in minute volume than the S infants and the controls. The rate of decline in minute volume was greater in the SM infants (p=0.008) and the S infants (p=0.011) compared with the controls.
CONCLUSIONS: Antenatal substance misuse and smoking affect the infant's ventilatory response to a hypoxic challenge.