Brain & development · 2026
Correlation between febrile seizures and cytokines in children: a retrospective study.
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Yu Dong, Hu Jia-Ni, Chen Yan-Fei, Bian Xue-Ying, Jiang Biao, Zhang Ning-Er, Shao Xiao-Li
Аннотация
OBJECTIVES: To analyze the correlation between cytokine levels and the occurrence of febrile seizures (FS) following respiratory tract infections in children.
METHODS: A total of 209 children with febrile seizures (FS) secondary to respiratory tract infections, treated at the Department of Pediatric Internal Medicine, Shaoxing People's Hospital, between January 2023 and March 2024, were enrolled as the FS group. During the same period, 108 children with respiratory tract infections but without FS were selected as the control group. The association between FS and the immune response was analyzed by comparing cytokine levels between the two groups.
RESULTS: Interleukin-2 (IL-2) and IL-6 levels were higher in the FS group than in the control group (children with respiratory tract infections but without FS) (P < 0.05). Younger age was associated with higher levels of IL-10 and IFN-γ (P < 0.05). IL-2 levels were highest during the early stage of seizures (P < 0.05). A greater number of seizure episodes was associated with lower levels of IFN-γ (P < 0.05). IL-6 levels were lower in children with FS who had a history of seizures than in those without such a history (P < 0.05). A serum IFN-γ level exceeding 21.60 pg/mL may serve as a reference index for identifying children at high risk of seizure recurrence.
CONCLUSION: IL-2 and IL-6 levels are elevated in children with FS. Furthermore, age, seizure frequency, and a history of prior seizures may influence cytokine levels in these patients.
METHODS: A total of 209 children with febrile seizures (FS) secondary to respiratory tract infections, treated at the Department of Pediatric Internal Medicine, Shaoxing People's Hospital, between January 2023 and March 2024, were enrolled as the FS group. During the same period, 108 children with respiratory tract infections but without FS were selected as the control group. The association between FS and the immune response was analyzed by comparing cytokine levels between the two groups.
RESULTS: Interleukin-2 (IL-2) and IL-6 levels were higher in the FS group than in the control group (children with respiratory tract infections but without FS) (P < 0.05). Younger age was associated with higher levels of IL-10 and IFN-γ (P < 0.05). IL-2 levels were highest during the early stage of seizures (P < 0.05). A greater number of seizure episodes was associated with lower levels of IFN-γ (P < 0.05). IL-6 levels were lower in children with FS who had a history of seizures than in those without such a history (P < 0.05). A serum IFN-γ level exceeding 21.60 pg/mL may serve as a reference index for identifying children at high risk of seizure recurrence.
CONCLUSION: IL-2 and IL-6 levels are elevated in children with FS. Furthermore, age, seizure frequency, and a history of prior seizures may influence cytokine levels in these patients.