Heart & lung : the journal of critical care · 2026
DisCONtinuing aspirin for Cardiac Allograft Vasculopathy prophylaxis in heart transplant patients on concurrEnt anticoagulation (CONCAVE).
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Bill Alicia, Blaine Bruce E, Godishala Anuradha, Martens John, Lloji Amanda, Chen YeeAnn
Аннотация
BACKGROUND: Early aspirin initiation after orthotopic heart transplant (OHT) has been associated with delayed progression of cardiac allograft vasculopathy (CAV). There is limited guidance on whether aspirin for CAV prophylaxis should be continued in the setting of therapeutic anticoagulation.
OBJECTIVES: The purpose of this study is to compare the safety and efficacy of two antithrombotic strategies, anticoagulation alone (AC) versus combined anticoagulation and aspirin (AC+ASA), for patients with indications for therapeutic anticoagulation.
METHODS: This was a single-center, retrospective, and observational cohort study of adult OHT recipients. The primary outcome was major bleeding within the first month of starting anticoagulation. Secondary outcomes included clinically relevant non-major bleeding, major bleeding within the first three months and first year of anticoagulation therapy, incidence of CAV, and death.
RESULTS: Among the 126 patients included in the primary analysis, there were five and 19 major bleeding events in the AC group and AC+ASA group, respectively (p = 0.649). The AC group had 14.3 times higher odds of death than the AC+ASA group (OR 0.07, 95 % CI 0.01-0.32). There were no differences in other secondary outcomes.
CONCLUSION: In our cohort, there was no evidence of a difference between groups for major bleeding within one month of anticoagulation initiation. Future research focusing on appropriateness of therapeutic anticoagulation in the acute period after transplant where patients are at an increased risk of bleeding may be beneficial.
OBJECTIVES: The purpose of this study is to compare the safety and efficacy of two antithrombotic strategies, anticoagulation alone (AC) versus combined anticoagulation and aspirin (AC+ASA), for patients with indications for therapeutic anticoagulation.
METHODS: This was a single-center, retrospective, and observational cohort study of adult OHT recipients. The primary outcome was major bleeding within the first month of starting anticoagulation. Secondary outcomes included clinically relevant non-major bleeding, major bleeding within the first three months and first year of anticoagulation therapy, incidence of CAV, and death.
RESULTS: Among the 126 patients included in the primary analysis, there were five and 19 major bleeding events in the AC group and AC+ASA group, respectively (p = 0.649). The AC group had 14.3 times higher odds of death than the AC+ASA group (OR 0.07, 95 % CI 0.01-0.32). There were no differences in other secondary outcomes.
CONCLUSION: In our cohort, there was no evidence of a difference between groups for major bleeding within one month of anticoagulation initiation. Future research focusing on appropriateness of therapeutic anticoagulation in the acute period after transplant where patients are at an increased risk of bleeding may be beneficial.