Pyrazole Amide Scaffolds in Agricultural Chemistry: From Molecular Design to Applications.

Pyrazole amide compounds exhibit a wide range of biological activities, which enables them to hold an important position in the field of pesticide research. The pyrazole ring has characteristics such as multiple substitution sites, a wide optimization space, a unique mechanism of action, and no cross-resistance; the amide moiety represents a highly prevalent structural motif. It is frequently chosen as a pivotal pharmacophore and incorporated into the molecular architecture of compounds to enhance the relevant biological activities. Analyzing the concise structure-activity relationships (SAR) of pyrazole amide fragments featuring high-efficiency activity and summarizing their characteristics constitute pivotal steps in the development of novel pesticides. This article aims to introduce readers to pyrazole amide compounds with insecticidal, nematicidal, fungicidal, bactericidal, herbicidal, and antiviral properties. It categorizes these compounds to aid in rapid comprehension and offers references for the development of novel pyrazole amide compounds.