Analyzing Frailty Trajectories and Predictive Factors in Older Chinese Adults: A Group-Based Trajectory Modeling.

BACKGROUND

Existing interventions for geriatric frailty have demonstrated limited overall efficacy, underscoring the need to identify more precise frailty trajectories and develop targeted therapeutic strategies. Although substantial research has examined frailty prevalence among Chinese older adults, few studies have explored longitudinal trajectories, and limited evidence suggests that patterns resemble those observed in other countries. This study aims to identify distinct frailty trajectories and their multidimensional predictors, thereby informing personalized interventions to slow frailty progression.

METHODS

This study analyzed data from 11,988 participants across four waves (2008-2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Using group-based trajectory modeling (GBTM), we iteratively fitted models of varying orders to identify optimal frailty development patterns in the elderly population. Next, frailty index (FI) levels and trajectory group effects were assessed using generalized estimating equations (GEEs). Finally, multinomial logistic regression was employed to identify multidimensional predictors of trajectory group membership.

RESULTS

The optimal classification of frailty trajectories among Chinese older adults identified three groups: the low and stable group (53.0%), the moderate increasing group (28.4%), and the high-level frailty group (18.7%). The GEE analysis revealed significant differences in frailty trajectories among participants (p < 0.05). Multinomial logistic regression results indicated that gender, age, education, residence, residential status, economic status, dietary diversity (DD), alcohol consumption, physical activity, cognitive activity, social activity, anxiety, and loneliness were significant predictors of frailty trajectory membership (p < 0.05). The high-risk group exhibited a "cumulative disadvantage" profile characterized by female sex, age ≥85 years, rural residence, low economic status, experience of childhood hunger, moderate alcohol consumption, poor DD, physical inactivity, low cognitive activity, severe anxiety, pronounced loneliness, and low social participation.

CONCLUSION

This study identified three distinct frailty trajectories among older adults, revealing that high-risk groups face a "cumulative disadvantage" arising from the convergence of socioeconomic deprivation, behavioral risks, and psychological vulnerability. These findings underscore the need for targeted early interventions and personalized management strategies to effectively address frailty.

CLINICAL STUDY REGISTRATION: Not applicable.