Lasers in surgery and medicine · 2025
Clinical Efficacy Analysis of Hematoporphyrin Monomethyl Ether Photodynamic Therapy for Port-Wine Stain.
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Li Minghui, Song Yang, Chen Yao, Zhou Junfeng
Аннотация
OBJECTIVE: To explore the related influencing factors of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) for port-wine stain(PWS) and evaluate the relationship between dermoscopic vascular patterns and treatment efficacy.
METHODS: Retrospective analysis of 182 PWS patients (November 2017 to November 2023) who received HMME-PDT. Among them, 51 patients had dermoscopy before treatment. Demographic (age, gender), clinical (lesion location, colors, size, treatments), and dermoscopic data (vascular patterns) were collected. Efficacy was assessed via pre-/post-treatment photos (classified as complete regression, good improvement, slight improvement, or no improvement), and adverse reactions were recorded. SPSS 26.0 was used for statistical analysis.
RESULTS: Among 182 PWS patients, HMME-PDT achieved an overall response rate of 77.5% (141/182), with 23.6% (43) showing complete regression, 15.9% (29) demonstrating good improvement, and 37.9% (69) experiencing slight improvement; 22.5% (41) showed no improvement. Efficacy significantly correlated with age, lesion location, color, size, and treatments (p < 0.05), but not with gender or facial partition (V1, V2, V3) (p > 0.05). Multivariate analysis identified small lesion size, facial and neck, pink and purplish red lesions as positive predictors, while fewer treatment sessions were unfavorable. Seven cases (3.85%) developed long-term adverse effects (5 scars, 2 hyperpigmentations). Dermoscopic analysis of 51 vascular patterns revealed significant efficacy differences among pattern types (p < 0.05), with type I (23.5%), type II (43.2%), and type III (29.4%) showing distinct therapeutic responses.
CONCLUSION: HMME-PDT efficacy correlates with age, lesion location, color, size, and treatments, but not gender and facial partition (V1, V2, V3). Dermoscopic vascular patterns can predict treatment response, with type I being the most effective.
METHODS: Retrospective analysis of 182 PWS patients (November 2017 to November 2023) who received HMME-PDT. Among them, 51 patients had dermoscopy before treatment. Demographic (age, gender), clinical (lesion location, colors, size, treatments), and dermoscopic data (vascular patterns) were collected. Efficacy was assessed via pre-/post-treatment photos (classified as complete regression, good improvement, slight improvement, or no improvement), and adverse reactions were recorded. SPSS 26.0 was used for statistical analysis.
RESULTS: Among 182 PWS patients, HMME-PDT achieved an overall response rate of 77.5% (141/182), with 23.6% (43) showing complete regression, 15.9% (29) demonstrating good improvement, and 37.9% (69) experiencing slight improvement; 22.5% (41) showed no improvement. Efficacy significantly correlated with age, lesion location, color, size, and treatments (p < 0.05), but not with gender or facial partition (V1, V2, V3) (p > 0.05). Multivariate analysis identified small lesion size, facial and neck, pink and purplish red lesions as positive predictors, while fewer treatment sessions were unfavorable. Seven cases (3.85%) developed long-term adverse effects (5 scars, 2 hyperpigmentations). Dermoscopic analysis of 51 vascular patterns revealed significant efficacy differences among pattern types (p < 0.05), with type I (23.5%), type II (43.2%), and type III (29.4%) showing distinct therapeutic responses.
CONCLUSION: HMME-PDT efficacy correlates with age, lesion location, color, size, and treatments, but not gender and facial partition (V1, V2, V3). Dermoscopic vascular patterns can predict treatment response, with type I being the most effective.