Prolonged galactorrhoea in a 6-year-old girl with isosexual precocious puberty due to a feminizing adrenal tumour.

A large cystic adrenal carcinoma was removed in toto from a 6 1/2-year-old girl with isosexual precocious puberty treated with cyproterone-acetate. Immediately following surgery, sever galactorrhoea developed, but was successfully treated with bromocriptine. The tumour fluid and pre-operative plasma samples contained highly elevated levels of both oestrogens and androgens. In addition prolactin values were high. One year after adrenalectomy all plasma hormonal values were normal for age, but galactorrhoea could still be elicited. The prolonged galactorrhoea is most likely the result of excessive oestrogen 'priming', whereas the hyperprolactinaemic effect of cyproterone acetate therapy remains uncertain.