Journal de gynecologie, obstetrique et biologie de la reproduction · 1994
[A new therapeutic strategy using a ofloxacin-amoxicillin-clavulanic acid combination in the treatment of upper gynecologic infections. Apropos of 123 cases].
Клиническое исследованиеАннотация на английскомСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Verhoest P, Fernandez H, Henry-Suchet J, Orfila J, Boulanger J C
Аннотация
OBJECTIVE: To evaluate a new antibiotic strategy with a combination of ofloxacin + co-amoxiclav in the treatment of pelvic infectious diseases.
DESIGN: An open-non-comparative multicentre (10) study.
SUBJECTS: 123 patients (118 salpingitis and 5 endometritis) were included clinical, laparoscopic and bacteriological assessments were performed before treatment and a laparoscopic control was done in 35% of cases. Among positive bacteriological samples before treatment 48.7% C. trachomatis were isolated; 56.1% of salpingitis were considered as severe (COGIT score > 6).
TREATMENT: Patients received at entry oral ofloxacin 200 mg bid in combination with parenteral co-amoxiclav 2 to 4 g following by oral route. Total duration of treatment was 21 days.
RESULTS: With respectively 97.2% and 91.6% satisfactory clinical and bacteriological results, this combination should take a major place in the treatment of pelvic infectious diseases.
DESIGN: An open-non-comparative multicentre (10) study.
SUBJECTS: 123 patients (118 salpingitis and 5 endometritis) were included clinical, laparoscopic and bacteriological assessments were performed before treatment and a laparoscopic control was done in 35% of cases. Among positive bacteriological samples before treatment 48.7% C. trachomatis were isolated; 56.1% of salpingitis were considered as severe (COGIT score > 6).
TREATMENT: Patients received at entry oral ofloxacin 200 mg bid in combination with parenteral co-amoxiclav 2 to 4 g following by oral route. Total duration of treatment was 21 days.
RESULTS: With respectively 97.2% and 91.6% satisfactory clinical and bacteriological results, this combination should take a major place in the treatment of pelvic infectious diseases.
Предметные рубрики MeSH
AdolescentAdultAmoxicillinAnti-Bacterial AgentsBacterial InfectionsChlamydia InfectionsChlamydia trachomatisClavulanic AcidClavulanic AcidsDrug Therapy, CombinationDrug ToleranceEndometritisFemaleFollow-Up StudiesGenital Diseases, FemaleHumansMiddle AgedOfloxacinPelvic Inflammatory DiseaseRemission InductionSalpingitisbeta-Lactamase Inhibitorsbeta-Lactamases