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Войти в исследования Journal of veterinary internal medicine · 2020
Aventriculi associated with holoprosencephaly in a dog.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Barnard Laura, Durand Alexane, Blume Lauren, Lee Laura, Cameron Starr
Аннотация
CASE DESCRIPTION: A 10-month-old neutered male mixed breed dog was presented for assessment of poorly controlled seizures.
CLINICAL FINDINGS: Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE).
CLINICAL RELEVANCE: To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.
CLINICAL FINDINGS: Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE).
CLINICAL RELEVANCE: To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.