Early human development · 2026
Relationships between sequential MRI in the neonatal period and early motor repertoire in very preterm infants.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
George Joanne M, Kwong Amanda K L, Pannek Kerstin, Fiori Simona, Luke Carly, Finn Christine, Biagioni Tommaso, Bonezzi Linda, Gordon Anya, Guzzetta Andrea, Chatfield Mark D, Ware Robert S, Colditz Paul B, Boyd Roslyn N
Аннотация
BACKGROUND: Infants born very preterm frequently experience neurodevelopmental challenges. Early detection enables provision of targeted interventions to improve outcomes. Early neonatal and term-equivalent age (TEA) MRI and 3-5-month corrected age (CA) Prechtl Motor Optimality Score - revised (MOS-R) are useful prognostic tools, however structure-function relationships between them are not well established.
METHODS: Infants born <31 weeks' gestation underwent MRI at 32-weeks postmenstrual age and TEA. Modified Kidokoro MRI scoring generated white matter, cortical grey matter, deep grey matter and cerebellar scores which were summed to produce a global score. Infant MOS-R was assessed from videos recorded at 3-4 months' CA. Relationships between MRI abnormality scores and MOS-R and absent fidgety general movements were modelled using regression analysis.
RESULTS: Brain MRI was performed at 32-weeks in 249 infants, of whom 221 had TEA MRI and 225 had a MOS-R. For 32-week MRI, white matter, deep grey matter and global scores were related to MOS-R (global βMOS-R = -0.27, 95% confidence interval [CI] -0.46, -0.08; p = 0.006) and absent fidgety movements (global odds ratio = 1.23, 95%CI 1.07, 1.40; p = 0.003). For TEA MRI, white matter and global scores were related to MOS-R (global βMOS-R = -0.26, 95%CI -0.47, -0.06; p = 0.01) and absent fidgety movements (global odds ratio = 1.23, 95%CI 1.05, 1.42; p = 0.008). In multivariable model including global scores from both timepoints, term equivalent MRI scores remained related to MOS-R (βMOS-R = -0.41, 95%CI -0.72, 0.10; p = 0.009).
CONCLUSION: Early and TEA MRI are related to MOS-R and general movements assessment. Term MRI global scores are independently related to MOS-R at 3-4 months' corrected age. This has implications for prioritising infants with poorer MRI scores for early assessment and that poorer MOS-R scores may be a manifestation of changes to brain structure and due to preterm birth.
METHODS: Infants born <31 weeks' gestation underwent MRI at 32-weeks postmenstrual age and TEA. Modified Kidokoro MRI scoring generated white matter, cortical grey matter, deep grey matter and cerebellar scores which were summed to produce a global score. Infant MOS-R was assessed from videos recorded at 3-4 months' CA. Relationships between MRI abnormality scores and MOS-R and absent fidgety general movements were modelled using regression analysis.
RESULTS: Brain MRI was performed at 32-weeks in 249 infants, of whom 221 had TEA MRI and 225 had a MOS-R. For 32-week MRI, white matter, deep grey matter and global scores were related to MOS-R (global βMOS-R = -0.27, 95% confidence interval [CI] -0.46, -0.08; p = 0.006) and absent fidgety movements (global odds ratio = 1.23, 95%CI 1.07, 1.40; p = 0.003). For TEA MRI, white matter and global scores were related to MOS-R (global βMOS-R = -0.26, 95%CI -0.47, -0.06; p = 0.01) and absent fidgety movements (global odds ratio = 1.23, 95%CI 1.05, 1.42; p = 0.008). In multivariable model including global scores from both timepoints, term equivalent MRI scores remained related to MOS-R (βMOS-R = -0.41, 95%CI -0.72, 0.10; p = 0.009).
CONCLUSION: Early and TEA MRI are related to MOS-R and general movements assessment. Term MRI global scores are independently related to MOS-R at 3-4 months' corrected age. This has implications for prioritising infants with poorer MRI scores for early assessment and that poorer MOS-R scores may be a manifestation of changes to brain structure and due to preterm birth.