The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia.

OBJECTIVE

To explore the diagnostic value of Matrix Metallopeptidase 7 (MMP-7) alongside serological markers in identifying liver fibrosis in children with biliary atresia (BA).

METHODS

A retrospective study was conducted to analyze the general information, liver fibrosis stage, and laboratory results, including MMP-7, of children with BA who underwent Kasai portoenterostomy between 2022 and 2024 at two Chinese hospitals. The aspartate aminotransferase to platelet ratio index (APRI), Fibrosis 4 Score (FIB-4), and infant biliary atresia liver fibrosis (iBALF) score were calculated according to the formula.

RESULTS

Significant differences in APRI, FIB-4, iBALF score, and MMP-7 were observed across fibrosis stages.When differentiating different stages of liver fibrosis, FIB-4 demonstrated the highest AUC values (0.807 and 0.815) for identifying liver fibrosis stages ≥ F2 and ≥ F3, and the optimal cut-off values were 0.073 and 0.105. For evaluating stage F4, MMP-7 showed the highest AUC value of 0.793, with an optimal cut-off of 68.94. Combining MMP-7 with other markers improved diagnostic accuracy, particularly MMP-7 + iBALF score for cirrhosis (F4: AUC = 0.844).

CONCLUSION

Serological markers like FIB-4, iBALF score, and MMP-7 can reflect various levels of liver fibrosis. Among these, the combination of MMP-7 and iBALF score is the most effective in differentiating liver cirrhosis.