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DOI 10.25011/cim.v31i3.3474

Медицинская библиотека · Clinical and investigative medicine. Medecine clinique et experimentale · 2008

The relationship between cervical human papillomavirus infection and apoptosis.

Fidan Isil, Bozdayi Gulendam, Rota Seyyal, Biri Aydan, Gurelik Feryal Cetin, Yuksel Sevgi, Imir Turgut

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

PURPOSE: Cervical carcinoma is the second most common cancer among women worldwide. Viral infections, especially human papillomavirus (HPV) infections, are important factors in its etiology. Changes in apoptotic regulation are considered to have an important role in the carcinogenesis development. In this study, the relationship between apoptosis and HPV infection was investigated.

METHODS

HPV DNA and HPV DNA type 16 positivity were detected in 110 cervical smear samples with Real Time PCR and sequencing was performed for HPV DNA type 18. The presence of apoptosis was investigated using TUNEL and Annexin V staining methods and analyzed by fluorescence microscope and flow cytometry.

RESULTS

HPV DNA type 16 was detected in 9 samples (8.1%), HPV DNA type 18 positive in 6 samples (5.4%) and HPV types other than HPV type 16 and HPV type 18 in 9 samples (8.1%). A decrease apoptosis was found in HPV DNA positive samples compared with controls (P < 0.05).

CONCLUSION

The decrease of apoptosis during HPV infection might cause cellular immortality and then malignant transformation.

Для цитирования: Fidan Isil, Bozdayi Gulendam, Rota Seyyal, Biri Aydan, Gurelik Feryal Cetin, Yuksel Sevgi, Imir Turgut. The relationship between cervical human papillomavirus infection and apoptosis.. Clinical and investigative medicine. Medecine clinique et experimentale. 2008. DOI: 10.25011/cim.v31i3.3474.

Предметные рубрики MeSH

Annexin A5ApoptosisCervix UteriFemaleFlow CytometryHuman papillomavirus 16HumansPapillomaviridaePapillomavirus InfectionsUterine Cervical NeoplasmsUterine Cervicitis
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